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How Can We Predict Malignancy of Thyroid Nodules with AUS/FLUS from Ultrasonographic Features?
J Surg Ultrasound 2018;5:45-52
Published online November 30, 2018
© 2018 The Korean Surgical Ultrasound Society

Eun Young Kim, Cheol Seung Kim, Young Sam Park, Eun Hye Choi, Mi Jin Kim

Division of Breast and Thyroid Surgery, Department of General Surgery, Presbyterian Medical Center, Jeonju, Korea
Correspondence to: Cheol Seung Kim
Division of Breast and Thyroid Surgery, Department of General Surgery, Presbyterian Medical Center, 365 Seowon-ro, Wansan-gu, Jeonju 54987, Korea
Tel: +82-63-230-1408
Fax: +82-63-230-1409
Received September 12, 2018; Revised November 14, 2018; Accepted November 19, 2018.
Journal of Surgical Ultrasound is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Purpose: Atypia/follicular lesions of undetermined significance (AUS/FLUS) as Bethesda System category 3, cannot be classified as benign or malignant. The purpose of this study was to identify which clinical factor increases the risk of malignancy in patients with AUS/FLUS.
Methods: A total of 158 patients with AUS/FLUS, who underwent thyroid surgery at the authors’ institution, were examined retrospectively. Chi square analyses were performed to compare the benign and malignancy group based on their final pathology to assess the independent effects of risk factors, such as age, sex, size of nodule, the number of FNAC, ultrasonography findings, and the number of malignancy ultrasonography findings in a single nodule.
Results: In the analyses, age, sex, the number of FNAC, contents, and shape were not significantly related to the cancer diagnosis. Marked hypoechogenicity, spiculated margin, microcalcification, and showing three or more ultrasonographic risk features were significantly related to an increased malignant risk.
Conclusion: Surgical resection of thyroid nodules should be considered in an AUS group showing three or more ultrasonographic risk findings.
Keywords : AUS, Thyroid nodule, Ultrasonography, Malignant, FNAC

November 2018, 5 (2)